It gets very high safety ratings. The brakes are OK as far as we know but we have not had to execute a panic stop to see how they would respond to that.
The interior materials are of high quality and the seats are very comfortable. There is a lot of room inside for the exterior dimensions of the car.
It is fairly quiet, at least for a Honda, and the ride is very comfortable. It also corners and handles well for a SUV.
We have gotten as high as 35 mpg on the highway under optimal conditions. It does not do as well in town, usually running around 18, but we drive the Prius in town and use the CR-V for road trips.