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Model Year Body/Powertrain MPG  
2015 2015 4dr Sedan 290-hp 3.5L V6 9-sp shiftable automatic AWD 29.9
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With the turbocharged 355hp 3.0L V6 engine, 10-speed shiftable automatic transmission, and all-wheel drive, the 2015 Acura TLX has been averaging 29.9 MPG (miles per gallon).

The 2015 Acura TLXs in this analysis were driven mostly on the highway at an average speed of 65 miles per hour (about 62.5 percent of the miles driven). The rest of the miles were in the city (7.5 percent), in the suburbs (0 percent), and in heavy traffic (0 percent).

In addition, the average 2015 Acura TLX in this analysis was driven on hilly terrain with a medium foot and the AC on only some of the time.
2015 2015 4dr Sedan 290-hp 3.5L V6 9-sp shiftable automatic FWD 35.58
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TrueDelta Reviews the Real Gas Mileage of the Acura TLX

Acura TLX Real Gas Mileage: Pros
2015 Compared to the Honda Accord, the Acura TLX has stronger engines and different, more performance-oriented transmissions. As a result, fuel economy takes a bit of a hit. Focusing on the four-cylinder, the EPA ratings are 27/36 for the Honda and 24/35 for the Acura. The latter is a nice bump over the 22/31 of last year's TSX, though, and also compares favorably to the MKZ's 22/33. In my driving, the trip computer reported averages ranging between 24 and 36 mpg in the suburbs (the high number when I was especially easy on the pedals) and high 30s on the highway. Of course, if fuel economy is a priority you can get the MKZ in hybrid form. Acura offers no such option. But the MKZ Hybrid is relatively sluggish. If you want a combination of good performance and good fuel economy in the same car (if not during the same drive), the TLX 2.4 has an edge. see full Acura TLX review

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Acura TLX Gas Mileage (MPG)

Unlike other fuel economy surveys, TrueDelta's Real-World Gas Mileage Survey includes questions about how and where a car was driven. So you can get an idea of the Acura TLX's real-world MPG based on how and where you drive a car.