I'm just going to list the issues based on carcomplaints.com and TrueDelta.
The A/C blend door is a common complaint. It's what controls the A/C and whether it is on recirculation fresh air or defrost. $500 fix
The engine randomly dies and stalls often for no reason. Some say it's the power module. $900 fix
There is also a thing owners call the "death wobble". The truck violently shakes when going +65 mph. The shaking makes it hard to control the truck and is a safety issue. expensive
Starting with 2008, the 4x4 system would not engage and become stuck.
The 2010 was more reliable than the previous years.