Reliability tends to be a strong point of the RX models. Lexus/Toyota tests their vehicles in extreme climate conditions for extended periods. The climate control systems perform longer than other brands without problems. So, I wouldn't be concerned about that. Like anything, they can break down. For mechanical repairs, any repair shop that works on Toyotas can repair them since they are basically Toyotas mechanically speaking. A 1999 Ford may have cheaper parts, but you will repair it more often and the Ford may end up ultimately costing you more.