Is all-wheel-drive also a requirement?
Are the long trips at highway speed?
You'll get middling fuel economy out of the CR-V and Escape. Reliability has been very good with the Honda, but questionable with the 2006 Ford (2007-2012 have been better).
Vehicles some courier services in the survey have driven for many miles include the Honda Fit, Pontiac Vibe, and Toyota Matrix (the last two are the same except for styling). All three would have plenty of space for the papers.