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The three you mention are certainly capable of your needs, although I think you will find the MDX has quite a bit smaller interior. One more vehicle I will throw on the "wall of consideration" is the Nissan Armada. It is the sister to the Infinity and I do not believe they offer a hybrid, but as my son says about his fully loaded one, "There is nothing like taking a trip in the comfort of your living room."

Do a lot of research on the large SUV hybrids. The manufacturers felt a push to offer them, and a few models, after only 1 or 2 years, have already been dropped from production. They are not as efficient as intended.

A fully loaded Armada will be as comfortable and luxurious as the QX60 but at a significantly less cost. Very reliable (my son's has 40k miles and the only warranty issue has been the gas struts on the rear tailgate) and you will have plenty of $$ left in your pocket for those trips to Disneyland.

The Nissan Pathfinder, Nissan Armada, and Infiniti JX/QX60 have all had reliability issues. Also, the Armada is an ancient design at this point. With the first two, the hybrid isn't much more fuel efficient than the regular gas engine.

If the Acura MDX has enough space for your needs, that's the way I'd go. Very good handling and fuel efficiency for a three-row crossover. Its first-year reliability score isn't great, but if history is any guide Honda will have sorted out the initial bugs. I'd just try to buy one made later in the model year, or even a 2015.